De moléculas a sociedades complejas: las restricciones de escala en la evolución a la complejidad
Publicado 2026-09-11
Palabras clave
- complejidad,
- evolución,
- escalamiento alométrico,
- sistemas complejos,
- transiciones evolutivas mayores
- multicelularidad ...Más
Descargas
Cómo citar
Derechos de autor 2026 Edwin Francisco Herrera-Paz (Autor/a)

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial-SinDerivadas 4.0.
Resumen
Los sistemas biológicos y sociotecnológicos evolucionan de configuraciones simples a complejas. Este trabajo plantea que las transiciones evolutivas mayores en individualidad (TEMI) ocurren cuando los sistemas alcanzan restricciones de escala derivadas de relaciones alométricas y físicas, lo que limita la evolución de la complejidad dentro de un nivel organizacional. Mediante ejemplos que van desde moléculas hasta sociedades humanas, se analiza cómo variables relacionadas con el intercambio de materia y energía, el transporte interno y la coordinación funcional escalan de forma no lineal con el crecimiento del sistema, generando ventajas iniciales, pero también límites estructurales. La transición evolutiva de una simple población de elementos a un individuo de orden superior suele darse en tamaños intermedios, donde los sistemas comienzan a experimentar saturación funcional debido a restricciones alométricas. En lugar de detenerse el crecimiento, la complejidad se redistribuye a un nivel superior mediante integración, cooperación y división del trabajo, como ocurre en la transición de moléculas a células, de células a organismos multicelulares, de insectos a colonias eusociales, y de mamíferos a sociedades humanas complejas. Así, las restricciones de escala explican la aparición recurrente de nuevos niveles de organización en sistemas biológicos y sociotecnológicos.
Referencias
- Abergel, C., & Claverie, J.-M. (2020). Giant viruses. Current Biology, 30(19), R1108–R1110. https://doi.org/10.1016/j.cub.2020.08.073
- Alexander, R. M. (1981). Factors of safety in the structure of animals. Science, 211(4480), 132–138. https://doi.org/10.1126/science.7444456
- Allen, D. (2014). How mechanics shaped the modern world. Springer. https://doi.org/10.1007/978-3-319-01701-3
- Bettencourt, L. M. A., Yang, V. C., Lobo, J., Kempes, C. P., Rybski, D., & Hamilton, M. J. (2020). The interpretation of urban scaling analysis in time. Journal of the Royal Society Interface, 17(163), 20190846. https://doi.org/10.1098/rsif.2019.0846
- Boudinot, B. E., Richter, A., Katzke, J., Chaul, J. C. M., Keller, R. A., & Economo, E. P. (2022). Evidence for the evolution of eusociality in stem ants and a systematic revision of Gerontoformica (Hymenoptera: Formicidae). Zoological Journal of the Linnean Society, 195(4), 1355–1389. https://doi.org/10.1093/zoolinnean/zlab097
- Brown, J. H., Gillooly, J. F., Allen, A. P., Savage, V. M., & West, G. B. (2004). Toward a metabolic theory of ecology. Ecology, 85(7), 1771–1789. https://doi.org/10.1890/03-9000
- Campli, G., & Scholtz, C. H. (2024). The moulting arthropod: A complete genetic toolkit review. Biological Reviews, 99(2), 345–369. https://doi.org/10.1111/brv.13123
- Canbäck, S., Samouel, P., & Price, D. (2006). Do diseconomies of scale impact firm size and performance? A theoretical and empirical overview. ICFAI Journal of Managerial Economics, 4(1), 27–70. https://ssrn.com/abstract=1267964
- Carmel, Y., & Shavit, A. (2020). Operationalizing evolutionary transitions in individuality. Proceedings of the Royal Society B: Biological Sciences, 287, 20192805. https://doi.org/10.1098/rspb.2019.2805
- Chouvenc, T., Su, N.-Y., & Robert, A. (2021). Termites emerged as eusocial wood-feeding roaches with extensive adaptive traits. Proceedings of the National Academy of Sciences, 118(3), e2021869118. https://doi.org/10.1073/pnas.2021869118
- Clapham, M. E., Karr, J. D., & Berner, R. A. (2012). Environmental and biotic controls on the evolutionary history of insect body size. Proceedings of the National Academy of Sciences of the United States of America, 109(Suppl. 1), 16246–16251. https://doi.org/10.1073/pnas.1204026109
- Cui, J., Schlub, T. E., & Holmes, E. C. (2014). An allometric relationship between the genome length and virion volume of viruses. Journal of Virology, 88(11), 6403–6410. https://doi.org/10.1128/JVI.00362-14
- Czarnoleski, M., & Verberk, W. C. E. P. (2025). Cell size matters: A unifying theory across the tree of life. Trends in Ecology & Evolution, 40(11), 1113–1125. https://doi.org/10.1016/j.tree.2025.09.003
- Dagan, T., & Martin, W. (2023). The last universal common ancestor between ancient Earth chemistry and the onset of genetics. Journal of Molecular Evolution, 91(6), 529–542. https://doi.org/10.1007/s00239-023-10114-6
- Dill, K. A., & MacCallum, J. L. (2012). The protein-folding problem, 50 years on. Science, 338(6110), 1042–1046. https://doi.org/10.1126/science.1219021
- Dobson, C. M. (2003). Protein folding and misfolding. Nature, 426(6968), 884–890. https://doi.org/10.1038/nature02261
- Dunbar, R. I. M., & Shultz, S. (2007). Evolution in the social brain. Science, 317(5843), 1344–1349. https://doi.org/10.1126/science.1145463
- Eigen, M., McCaskill, J., & Schuster, P. (1989). The molecular quasi-species. Advances in Chemical Physics, 75, 149–263. https://doi.org/10.1002/9780470142578.ch4
- Ellis, R. J. (2001). Macromolecular crowding: Obvious but underappreciated. Trends in Biochemical Sciences, 26(10), 597–604. https://doi.org/10.1016/S0968-0004(01)01938-7
- Gianni, E., Kwok, S. L. Y., Wan, C. J. K., Goeij, K., Clifton, B. E., Colizzi, E. S., Attwater, J., & Holliger, P. (2026). A small polymerase ribozyme that can synthesize itself and its complementary strand. Science. Advance online publication. https://doi.org/10.1126/science.adt2760
- Gilbert, S. F. (2014). Developmental biology (10th ed.). Sinauer Associates.
- Gómez-Márquez, J. (2025). The origin of life and cellular systems: A continuum from prebiotic chemistry to biodiversity. Life, 15(11), 1745. https://doi.org/10.3390/life15111745
- Hadarovich, A., Kuster, D., Romero Romero, M. L., & Toth-Petroczy, A. (2026). The evolution of biomolecular condensates. Annual Review of Cell and Developmental Biology, 41, 403–432. https://doi.org/10.1146/annurev-cellbio-101123-051723
- Heldstab, S. A., & Isler, K. (2022). The economics of brain size evolution in vertebrates. Current Biology, 32(13), R697–R708. https://doi.org/10.1016/j.cub.2022.04.096
- Herrera-Paz, E. F. (2015). Superorganismo universal: Una teoría de la evolución a la complejidad. CreateSpace Independent Publishing Platform.
- Herrera-Paz, E. F. (2022). A universal trend: Non-living, biological, and sociocultural/technological transitions in evolution towards complexity. ResearchGate Preprint. https://doi.org/10.13140/RG.2.2.19212.80003/2
- Herrera-Paz, E. F. (2019). Biodemography research and the history of Central American and northwestern South American populations. En D. H. Ubelaker & S. E. Colantonio (Eds.), Biological anthropology of Latin America: Historical development and recent advances (Smithsonian Contributions to Anthropology No. 51, pp. 127–148). Smithsonian Institution Scholarly Press.
- Herrera-Paz, E. F. (2025). Is humanity undergoing a transition to reproductive specialization? Insights on the evolution of modern societies to superorganisms. Revista Médica del Hospital General de México, 88, 88–95. https://doi.org/10.24875/HGMX.24000001
- Herrera-Paz, E. F. (2026). Evolución de la multicelularidad y de las sociedades humanas complejas: Los factores comunes en ambas transiciones. Innovare (en revisión).
- Kempes, C. P., Koehl, M. A. R., & West, G. B. (2019). The scales that limit: The physical boundaries of evolution. Frontiers in Ecology and Evolution, 7, 242. https://doi.org/10.3389/fevo.2019.00242
- Koch, A. L. (1996). What size should a bacterium be? A question of scale. Annual Review of Microbiology, 50, 317–348. https://doi.org/10.1146/annurev.micro.50.1.317
- Kretschmer, T., Leiponen, A., Schilling, M., & Vasudeva, G. (2022). Platform ecosystems as meta-organizations: Implications for platform strategies. Strategic Management Journal, 43(2), 405–424. https://doi.org/10.1002/smj.3250
- Linke, W. A. (2008). Sense and stretchability: The role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction. Cardiovascular Research, 77(4), 637–648. https://doi.org/10.1016/j.cardiores.2007.03.029
- Liu, Z., Li, Z., Zhang, Y., Mutukumira, A. N., Feng, Y., Cui, Y., & Wang, S. (2024). Comparing business, innovation, and platform ecosystems: A systematic review of the literature. Biomimetics, 9(4), 216. https://doi.org/10.3390/biomimetics9040216
- MacLean, E. L., Matthews, L. J., Hare, B., Nunn, C. L., Anderson, R. C., Aureli, F., et al. (2014). The evolution of self-control. Proceedings of the National Academy of Sciences of the United States of America, 111(20), E2140–E2148. https://doi.org/10.1073/pnas.1323533111
- Mann, M. (2012). The sources of social power: Volume 1. A history of power from the beginning to AD 1760. Cambridge University Press.
- Maynard Smith, J., & Szathmáry, E. (1995). The major transitions in evolution. Oxford University Press.
- Miao, L., Zhu, S., Yin, Z., Cui, H., & Yuan, X. (2024). A multicellular eukaryote from the early Mesoproterozoic and the origin of multicellularity. Science Advances, 10(4), eadk3208. https://doi.org/10.1126/sciadv.adk3208
- Noller, H. F. (2012). Evolution of protein synthesis from an RNA world. Cold Spring Harbor Perspectives in Biology, 4(4), a003681. https://doi.org/10.1101/cshperspect.a003681
- Rothier, P. S., Herrel, A., Benson, R. B. J., & Hedrick, B. P. (2025). Body mass evolution as a driver of morphological and ecological diversity in terrestrial mammals. BMC Ecology and Evolution, 25, 120. https://doi.org/10.1186/s12862-025-02393-9
- Sánchez Garduño, F., & Gutiérrez Sánchez, J. L. (2020). La alometría, una ley de potencias ubicua en la estructura de los seres vivos. INTER DISCIPLINA, 8(20), 11–22. https://doi.org/10.22201/ceiich.24485705e.2020.20.71181
- Savage, V. M., Gillooly, J. F., Brown, J. H., West, G. B., & Charnov, E. L. (2004). The predominance of quarter-power scaling in biology. Functional Ecology, 18(2), 257–282. https://doi.org/10.1111/j.0269-8463.2004.00856.x
- Shajani, Z., Sykes, M. T., & Williamson, J. R. (2011). Assembly of bacterial ribosomes. Annual Review of Biochemistry, 80, 501–526. https://doi.org/10.1146/annurev-biochem-062608-160432
- Silk, J. B. (2007). The adaptive value of sociality in mammalian groups. Philosophical Transactions of the Royal Society B, 362(1480), 539–559. https://doi.org/10.1098/rstb.2006.1994
- Sol, D., Bateman-Neubert, A., Noguer, L., & Taylor, A. H. (2025). The evolutionary puzzle of cognition: Challenges and insights from individual-based studies. Philosophical Transactions of the Royal Society B: Biological Sciences, 380(1929), 20240123. https://doi.org/10.1098/rstb.2024.0123
- Tan, C., Saurabh, S., Bruchez, M. P., Schwartz, R., & Leduc, P. (2013). Molecular crowding shapes gene expression in synthetic cellular nanosystems. Nature Nanotechnology, 8, 602–608. https://doi.org/10.1038/nnano.2013.132
- Turchin, P. (2016). Ultrasociety: How 10,000 years of war made humans the greatest cooperators on Earth. Beresta Books.
- West, G. B., Woodruff, W. H., & Brown, J. H. (2002). Allometric scaling of metabolic rate from molecules and mitochondria to cells and mammals. Proceedings of the National Academy of Sciences of the United States of America, 99(Suppl. 1), 2473–2478. https://doi.org/10.1073/pnas.012579799
- West, G. B., Brown, J. H., & Enquist, B. J. (1997). A general model for the origin of allometric scaling laws in biology. Science, 276(5309), 122–126. https://doi.org/10.1126/science.276.5309.122
- West, G. B., Brown, J. H., & Enquist, B. J. (1999). The fourth dimension of life: Fractal geometry and allometric scaling of organisms. Science, 284(5420), 1677–1679. https://doi.org/10.1126/science.284.5420.1677
- Westall, F. (2025). What the earliest evidence for life tells us about the early Earth. Philosophical Transactions of the Royal Society B: Biological Sciences, 380(1974), 20240106. https://doi.org/10.1098/rstb.2024.0106
- Williamson, O. E. (1981). The economics of organization: The transaction cost approach. American Journal of Sociology, 87(3), 548–577. https://doi.org/10.1086/227496
- Woods, H. A., & Casas, J. (2026). Architecture of the insect tracheal system driven by spatially varying limitation of oxygen and carbon dioxide transport. Journal of the Royal Society Interface, 23(234), 20250420. https://doi.org/10.1098/rsif.2025.0420
- Zhang, J. (2000). Protein-length distributions for the three domains of life. Trends in Genetics, 16(3), 107–109. https://doi.org/10.1016/S0168-9525(99)01922-8
